"Using a drug that causes short-term detriment or makes symptoms worse to treat a disease is a direct attack on the first rule of medicine which is 'do no harm,'" Bond said.
Buoyed by similar research on congestive heart failure, he persisted. Funded by the Sandler Program for Asthma Research he collaborated with pulmonologists in the Texas Medical Center for his first studies on mice.
"If I gave it a beta blocker, after one dose the mouse had more trouble breathing. But if I left him on it for 28 days, he became a normal mouse. He lost all the airway constriction that occurred with the model," he said.
The once bristling fellow researchers are opening up to Bond's research now in its second trials.