Film Review: "Splice"
The best word I've found to describe Splice is "grotesque." It has some very viscerally disgusting scenes and a disturbingly realistic character in Dren (creepily well-realized by newcomer Chanéac and the expert visual effects team), but the real grotesqueries are provided by the actions of our protagonists. Brody and Polley are believable as a pair of brilliant scientists, but their pursuit of greater heights inspires morbid curiosity and stomach-churning dread. While the film (thankfully) doesn't delve too deeply into the science at play, the ethics are all too familiar, especially given the current pace of scientific/technological advancement. The only disappointing aspect of the movie is the third act, which devolves into a generic-horror-movie chase scene, capped by predictable but unsettling ending. As far as recent "horror" movies go, Splice is one of the more affecting and effective I've seen.
In search of notoriety and new medicines, biochemists Clive and Elsa (Brody and Polley) create a hybrid creature containing human DNA. As their creation grows and matures, Clive and Elsa have to face the consequences of their tampering with biology. A well-made and timely horror story.